Sandbox Reserved 829: Difference between revisions
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Megane Denu (talk | contribs) No edit summary |
Megane Denu (talk | contribs) No edit summary |
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[[Image:Final.jpg|right|1000px|thumb|Differences between conformation A and B <ref> PMID: 23950697</ref> ]] | [[Image:Final.jpg|right|1000px|thumb|Differences between conformation A and B <ref> PMID: 23950697</ref> ]] | ||
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Actually, in conformation B, Gln 50 formes a water-mediated contact with Gua 5 and Thy 6* , and Asn 51 binds Ade 2 in addition to Ade 3. | Actually, in conformation B, Gln 50 formes a water-mediated contact with Gua 5 and Thy 6* , and Asn 51 binds Ade 2 in addition to Ade 3. | ||
[[Image:Nter.jpg|left|500px|thumb|PDX-1 homedomain/DNA interactions | |||
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A. Structure of the PDX-1 homedomain/DNA complex | |||
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B. Hydrogen bond contacts with the DNA differ between Conformation A and B | |||
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<ref> PMID: 23950697</ref> ]] | |||
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So, the most stable configuration for the N-terminal arm of Pdx1 consists of Lys 2 inserted in the minor groove and Arg 3 outside of the minor grove contacting the phosphate backbone and Arg 43. | So, the most stable configuration for the N-terminal arm of Pdx1 consists of Lys 2 inserted in the minor groove and Arg 3 outside of the minor grove contacting the phosphate backbone and Arg 43. | ||
