Sandbox Reserved 829: Difference between revisions
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== '''Structure of PDX-1 homeodomain''' == | == '''Structure of PDX-1 homeodomain''' == | ||
<ref> PMID: 17315980 </ref> <ref> PMID: 23950697</ref> | <ref> PMID: 17315980 </ref> <ref name = "binding" >PMID: 23950697</ref> | ||
===='''Generality''' ==== | ===='''Generality''' ==== | ||
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===='''Motifs of the PDX-1 homeodomain''' | ===='''Motifs of the PDX-1 homeodomain''' [[http://www.proteopedia.org/wiki/index.php/Image:Schematic_representation_of_functional_domains_and_phosphorylation_sites_of_PDX-1.jpg]] ==== | ||
The homeodomain contains a Protein Transduction Domain (PTD : from 188 to 203 amino acids) and a Nuclear Localization Signal motif (NLS : from 197 to 203 amino acids), which allow PDX-1 to permeate into cells. | The homeodomain contains a Protein Transduction Domain (PTD : from 188 to 203 amino acids) and a Nuclear Localization Signal motif (NLS : from 197 to 203 amino acids), which allow PDX-1 to permeate into cells. | ||
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Moreover, the two conformations of the Pdx1/DNA complex contained invariant contacts found in both conformations A and B, and variant contacts specific to each conformation. | Moreover, the two conformations of the Pdx1/DNA complex contained invariant contacts found in both conformations A and B, and variant contacts specific to each conformation. | ||
[[Image:Final.jpg|right|1000px|thumb|Differences between conformation A and B <ref | [[Image:Final.jpg|right|1000px|thumb|Differences between conformation A and B <ref name= "binding" />]] | ||
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<ref | <ref name= "binding" />]] | ||
