Sandbox Reserved 829: Difference between revisions
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The homeodomain protein folds into three α-helices, with helices 1 and 2 antiparallel to each other and perpendicular to helix 3, and a flexible N-terminal arm. | The homeodomain protein folds into three α-helices, with helices 1 and 2 antiparallel to each other and perpendicular to helix 3, and a flexible N-terminal arm. | ||
Helices 2 and 3 form a helix-turn-helix type motif. [http://en.wikipedia.org/wiki/Helix-turn-helix Wikipedia] | Helices 2 and 3 form a helix-turn-helix type motif. ([http://en.wikipedia.org/wiki/Helix-turn-helix Wikipedia]) | ||
Indeed this tertiary structure motif consists of two α-helices and a short extended amino acids chain between them. The more carboxyl-terminal helix can fit into the major groove of DNA. | Indeed this tertiary structure motif consists of two α-helices and a short extended amino acids chain between them. The more carboxyl-terminal helix can fit into the major groove of DNA. | ||
That is why, helix 3 (also known as the recognition helix) interacts with the the major groove of the DNA. | That is why, helix 3 (also known as the recognition helix) interacts with the the major groove of the DNA. | ||
