4f9g: Difference between revisions
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{{STRUCTURE_4f9g| PDB=4f9g | SCENE= }} | {{STRUCTURE_4f9g| PDB=4f9g | SCENE= }} | ||
===Crystal structure of STING complex with Cyclic di-GMP.=== | ===Crystal structure of STING complex with Cyclic di-GMP.=== | ||
{{ABSTRACT_PUBMED_22705373}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4f9g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4f9g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F9G OCA]. | ||
==See Also== | |||
*[[Stimulator of interferon genes|Stimulator of interferon genes]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022705373</ref><references group="xtra"/> | <ref group="xtra">PMID:022705373</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Kabaleeswaran, V.]] | [[Category: Kabaleeswaran, V.]] | ||
[[Category: Wu, H.]] | [[Category: Wu, H.]] | ||
