4jvj: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4jvj|  PDB=4jvj  |  SCENE=  }}
===Crystal structure of human FPPS in complex with magnesium, CL01131, and sulfate===
{{ABSTRACT_PUBMED_23998921}}


The entry 4jvj is ON HOLD  until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.


Authors: Park, J., Leung, C.-Y., Tsantrizos, Y.S., Berghuis, A.M.
==About this Structure==
[[4jvj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVJ OCA].  


Description: Crystal structure of human FPPS in complex with magnesium, CL01131, and sulfate
==Reference==
<ref group="xtra">PMID:023998921</ref><references group="xtra"/><references/>
[[Category: Berghuis, A M.]]
[[Category: Leung, C Y.]]
[[Category: Park, J.]]
[[Category: Tsantrizos, Y S.]]
[[Category: Transferase-transferase inhibitor complex]]
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