Sandbox Reserved 821: Difference between revisions
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This feature of amount increasing of the protein is currently used as a marker of inflammation in patients. | This feature of amount increasing of the protein is currently used as a marker of inflammation in patients. | ||
CRP | CRP belongs to the pentraxin family. | ||
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CRP is a pentamer: it contains five identical 23-kDa protomers, noncovalently associated (van der Waals contacts or hydrogen bonding) around a central pore. All members of the “pentraxins” family have this general structure. | CRP is a pentamer: it contains five identical 23-kDa protomers, noncovalently associated (van der Waals contacts or hydrogen bonding) around a central pore. All members of the “pentraxins” family have this general structure. | ||
Each protomer has a recognition face (also called face B) with a phosphocholine binding site (carrying two calcium ions), made of a two-layered β sheet. The other face - the effector face (or face A) - where complement C1q and Fc receptors bind, | Each protomer has a recognition face (also called face B) with a phosphocholine binding site (carrying two calcium ions), made of a two-layered β sheet. The other face - the effector face (or face A) - where complement C1q and Fc receptors bind, contains a single α helix. Consequently, the pentamer consists of five α helices on one side, and ten calcium ions on the other. | ||
== '''The Calcium and Phosphocholine binding sites''' == | == '''The Calcium and Phosphocholine binding sites''' == | ||
