Sandbox Reserved 820: Difference between revisions
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== Regulation of CASQ2 == | == Regulation of CASQ2 == | ||
CASQ2 can be phosphorylated by three different kinases: casein kinase I (CK I), casein kianse II (CK II) and ε protein kinase C1 (εPKC1). CK II is located in the SR and is able to phosphorylate Ser 378, Ser 382 and Ser 386. These residues are on the C-terminal domain. The consensus sequence recognized by CK II is Ser/Thr-X-X-Asp/Glu. More there are acidic residues after this consensus sequence, more the probabilty of phosphorylation increases. | |||
"The phosphorylation and de-phosphorylation of CASQ2 my provide an off/on switch for CASQ2 to regulate Ca2+" <!-- A reformuler, mais bon...! --> But there is not any prove yet. | |||
The p | |||
<!-- Source: Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004) Lien: http://www.ncbi.nlm.nih.gov/pubmed/15050380 --> | |||
There are <scene name='56/568018/Alpha_helix/1'>12 alpha helix</scene> and <scene name='56/568018/Beta_sheet/2'>15 beta sheet</scene>. | There are <scene name='56/568018/Alpha_helix/1'>12 alpha helix</scene> and <scene name='56/568018/Beta_sheet/2'>15 beta sheet</scene>. | ||
<scene name='56/568018/Acidic_amino_acids/1'>The acidics amino acids</scene> can bind the Ca2+ especially the <scene name='56/568018/Glu/2'>glutamate</scene> and the <scene name='56/568018/Asp/3'>aspartate</scene>. | <scene name='56/568018/Acidic_amino_acids/1'>The acidics amino acids</scene> can bind the Ca2+ especially the <scene name='56/568018/Glu/2'>glutamate</scene> and the <scene name='56/568018/Asp/3'>aspartate</scene>. | ||
