Sandbox Reserved 813: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Sarah Welly (talk | contribs) No edit summary |
Sarah Welly (talk | contribs) No edit summary |
||
| Line 52: | Line 52: | ||
==Homeodomain== | ==Homeodomain== | ||
The homeodomain is a very conserved 60 amino acid helix-turn helix DNA-binding domain. Its DNA sequence is called the “homeobox”, and the genes are known as “Hox gene”. The DNA recognition helix (alpha 3) binds the DNA major groove while the amino-terminal tail binds the DNA minor groove. We can draw a parallel with oct 1and oct2 about the Homeodomain and admit that the ninth residue of the DNA-recognition helix is a cysteine that might have been conserved at this position to confer DNA binding specificity , and promote more relaxed DNA sequence recognition by POU domains. The recognition helix and the inter-helix loops are rich in arginine and lysine residues, which form hydrogen bonds to the DNA backbone. | |||
= Applications = | = Applications = | ||
