Sandbox Reserved 823: Difference between revisions
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The best-studied SNAREs are the neuronal and the '''early endosomal SNARE complexes'''. The Neuronal SNARE complex mediates exocytosis of synaptic vesicles in the neurons and includes the vesicle protein synaptobrevin (also called VAMP), the membrane proteins SNAP-25 and syntaxin 1.<ref name="sutton" /> '''The early endosomal SNARE complex''' includes '''syntaxin 6, syntaxin 13, vti1a''' and '''VAMP4''' and is responsible for homotypic fusion of early endosomes.<ref> PMID: 16469845 </ref> It has been shown that the crystal structure of the early endosomal SNARE complex resembles that of the neuronal and late endosomal complexes, but differs in surface side-chain interactions. | The best-studied SNAREs are the neuronal and the '''early endosomal SNARE complexes'''. The Neuronal SNARE complex mediates exocytosis of synaptic vesicles in the neurons and includes the vesicle protein synaptobrevin (also called VAMP), the membrane proteins SNAP-25 and syntaxin 1.<ref name="sutton" /> '''The early endosomal SNARE complex''' includes '''syntaxin 6, syntaxin 13, vti1a''' and '''VAMP4''' and is responsible for homotypic fusion of early endosomes.<ref> PMID: 16469845 </ref> It has been shown that the crystal structure of the early endosomal SNARE complex resembles that of the neuronal and late endosomal complexes, but differs in surface side-chain interactions. | ||
== '''Membrane fusion mechanism''' == | == '''Membrane fusion mechanism''' == | ||
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[[Image:Snare_complex.jpg|thumbnail||600 px|| | [[Image:Snare_complex.jpg|thumbnail||600 px||right| '''Crystal structure of the early endosomal SNARE complex.''' | ||
(A) Backbone overlay of the early endosomal SNARE complex (in color) and the neuronal SNARE complex (gray). | (A) Backbone overlay of the early endosomal SNARE complex (in color) and the neuronal SNARE complex (gray). | ||
(B) N- to C-terminal view of the 0 layer containing the unusual aspartate in vti1a. (Color, early endosomal SNARE complex; gray, neuronal SNARE complex.) | (B) N- to C-terminal view of the 0 layer containing the unusual aspartate in vti1a. (Color, early endosomal SNARE complex; gray, neuronal SNARE complex.) | ||
