Sandbox Reserved 820: Difference between revisions
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=== Consequences of the bound of CASQ2 === | === Consequences of the bound of CASQ2 === | ||
When CASQ2 binds to triadin and junctin, it induces the inhibition of RyR and then the inhibition of calcium release in the cytoplasm. On the contrary, when CASQ2 unbinds triadin and junctin, it induces the activation of Ryr and an efflux of Ca<sup>2+</sup> from the SR to the cytoplasm.<ref name="Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004)">http://www.ncbi.nlm.nih.gov/pubmed/15050380</ref> CASQ2 is free when the concentration of Ca<sup>2+</sup> is higher than 1 mM in the SR lumen.<ref name="Regulation of Ryanodine Receptors by Calsequestrin: Effect of High Luminal Ca2+ and Phosphorylation (Beard et Al., 2005)">http://www.ncbi.nlm.nih.gov/pubmed/15731387</ref> | |||
<!-- Source: Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004) Lien: http://www.ncbi.nlm.nih.gov/pubmed/15050380 --> | <!-- Source: Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004) Lien: http://www.ncbi.nlm.nih.gov/pubmed/15050380 --> | ||
