Sandbox Reserved 827: Difference between revisions
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In case of some cancers, the permanent activation of TBK1 may be responsible of the proliferation of the cancerous cells. Since the substrates of TBK1 are involved in the proliferation pathway when phosphorylated, this permanent activation is a reason of the non apoptosis state of cells, and therefore of their proliferation. | In case of some cancers, the permanent activation of TBK1 may be responsible of the proliferation of the cancerous cells. Since the substrates of TBK1 are involved in the proliferation pathway when phosphorylated, this permanent activation is a reason of the non apoptosis state of cells, and therefore of their proliferation. | ||
=Additional 3D structures of TBK1= | |||
[http://www.rcsb.org/pdb/explore/explore.do?structureId=4IW0 4IW0], [http://www.rcsb.org/pdb/explore/explore.do?structureId=4IWP 4IWP], [http://www.rcsb.org/pdb/explore/explore.do?structureId=4IWQ 4IWQ], [http://www.rcsb.org/pdb/explore/explore.do?structureId=4IWO 4IWO] : mechanism of activation | |||
[http://www.rcsb.org/pdb/explore/explore.do?structureId=4IM0 4IM0], [http://www.rcsb.org/pdb/explore/explore.do?structureId=4IM2 4IM2], [http://www.rcsb.org/pdb/explore/explore.do?structureId=4IM3 4IM3] : global structure | |||
[http://www.rcsb.org/pdb/explore/explore.do?structureId=4EFO 4EFO] : structure of the ULD | |||
[http://www.rcsb.org/pdb/explore/explore.do?structureId=4EUT 4EUT], [http://www.rcsb.org/pdb/explore/explore.do?structureId=4EUU 4EUU] : structure of the kinase domain, with a phosphorylated S172 or an unphosphorylated one | |||
=See Also= | |||
= References = | = References = | ||
<references/> | <references/> | ||
[http://http://www.uniprot.org/uniprot/Q9UHD2 TBK1] in UniprotKB | |||
=Contributors= | |||
[[Léa Faivre]] , [[Gaëlle Gillet]] | |||
