Sandbox Reserved 822: Difference between revisions
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The PH domain of PDK1 reveals a structural variation of a standard PH domain fold with an additional bud at the N-terminus. | The PH domain of PDK1 reveals a structural variation of a standard PH domain fold with an additional bud at the N-terminus. | ||
Connsidering the structure, several different sections can be found which explain altogether the function of the PH domain. | Connsidering the structure, several different sections can be found which explain altogether the function of the PH domain. | ||
One section is a <scene name='56/568020/Barrel-like/3'>barrel-like structure</scene> formed by residues 456-530 (only shown on chain D). This structure is formed by two, almost orthogonal, β sheets, one consisting of four (β1 - β4) and one of three (β5 -β7) | One section is a <scene name='56/568020/Barrel-like/3'>barrel-like structure</scene> formed by residues 456-530 (only shown on chain D). This structure is formed by two, almost orthogonal, β sheets, one consisting of four (β1 - β4) and one of three (β5 - β7) stand. | ||
One side of the barrel is blocked by a <scene name='56/568020/Alpha1/1'>C-terminal alpha helix</scene>. | |||
On the other side of the barrel three variable loops (VL 1-3) form a bowl-like structure | |||
