Sandbox Reserved 819: Difference between revisions

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The bacterioruberin [http://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/22B], C50 H76 O4, is a 50 carbon carotenoid pigment which give a red color to the membrane. The primary role of bacterioruberin in the cell is to protect against DNA damage incurred by UV light.<ref>Shammohammadi, H.R., Protective roles of bacterioruberin and intracellular KCl in the resistance of ''Halobacterium salinarium'' against DNA-damaging agents, J Radiat Res, 1998, 39(4):251.</ref> This protection is not, however, due to the ability of bacterioruberin to absorb UV light. Bacterioruberin protects the DNA by acting as an antioxidant, rather than directly blocking UV light. It is able to protect the cell from reactive oxygen species produced from exposure to UV by acting as a target.

The bacterioruberin [http://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/22B], C50 H76 O4, is a 50 carbon carotenoid pigment which give a red color to the membrane. The primary role of bacterioruberin in the cell is to protect against DNA damage incurred by UV light.<ref>Shammohammadi, H.R., Protective roles of bacterioruberin and intracellular KCl in the resistance of ''Halobacterium salinarium'' against DNA-damaging agents, J Radiat Res, 1998, 39(4):251.</ref> This protection is not, however, due to the ability of bacterioruberin to absorb UV light. Bacterioruberin protects the DNA by acting as an antioxidant, rather than directly blocking UV light.<ref>Ide, H., Takeshi, S., Hiroaki, T., Studies on the antioxidation activity of bacterioruberin, Urakami Found Mem, 1998, 6:127–33.</ref>It is able to protect the cell from reactive oxygen species produced from exposure to UV by acting as a target.

Furthermore, the bacterioruberin is essential because it plays a structural role for the trimerization of aR2.

It binds to: the B chain thanks to a hydrogen bond with the <scene name='56/568017/Threonine_112/1'>Threonine 112</scene>, the <scene name='56/568017/Tyrosine/1'>Tyrosine 156</scene> and the HOH 304 thanks to an electrosatic bond; the D chain thanks to a hydrogen bond with the Tyrosine 156; the E chain thanks to a hydrogen bond with the Tyrosine 156.(others bonds exist like van-der-waals bonds [http://www.ebi.ac.uk/pdbe-site/pdbemotif/?tab=boundmolecule&pdb=2z55&ligandCode3letter=22B])

Sandbox Reserved 819: Difference between revisions

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-The bacterioruberin [http://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/22B], C50 H76 O4, is a 50 carbon carotenoid pigment which give a red color to the membrane. The primary role of bacterioruberin in the cell is to protect against DNA damage incurred by UV light.<ref>Shammohammadi, H.R., Protective roles of bacterioruberin and intracellular KCl in the resistance of ''Halobacterium salinarium'' against DNA-damaging agents, J Radiat Res, 1998, 39(4):251.</ref>  This protection is not, however, due to the ability of bacterioruberin to absorb UV light. Bacterioruberin protects the DNA by acting as an antioxidant, rather than directly blocking UV light. It is able to protect the cell from reactive oxygen species produced from exposure to UV by acting as a target.
+The bacterioruberin [http://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/22B], C50 H76 O4, is a 50 carbon carotenoid pigment which give a red color to the membrane. The primary role of bacterioruberin in the cell is to protect against DNA damage incurred by UV light.<ref>Shammohammadi, H.R., Protective roles of bacterioruberin and intracellular KCl in the resistance of ''Halobacterium salinarium'' against DNA-damaging agents, J Radiat Res, 1998, 39(4):251.</ref>  This protection is not, however, due to the ability of bacterioruberin to absorb UV light. Bacterioruberin protects the DNA by acting as an antioxidant, rather than directly blocking UV light.<ref>Ide, H., Takeshi, S., Hiroaki, T., Studies on the antioxidation activity of bacterioruberin, Urakami Found Mem, 1998, 6:127&ndash;33.</ref>It is able to protect the cell from reactive oxygen species produced from exposure to UV by acting as a target.
 Furthermore, the bacterioruberin is essential because it plays a structural role for the trimerization of aR2.
 It binds to: the B chain thanks to a hydrogen bond with the <scene name='56/568017/Threonine_112/1'>Threonine 112</scene>, the <scene name='56/568017/Tyrosine/1'>Tyrosine 156</scene> and the HOH 304 thanks to an electrosatic bond; the D chain thanks to a hydrogen bond with the Tyrosine 156; the E chain thanks to a hydrogen bond with the Tyrosine 156.(others bonds exist like van-der-waals bonds [http://www.ebi.ac.uk/pdbe-site/pdbemotif/?tab=boundmolecule&pdb=2z55&ligandCode3letter=22B])