Sandbox Reserved 821: Difference between revisions
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Léa Chuzel (talk | contribs) No edit summary |
Léa Chuzel (talk | contribs) No edit summary |
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The role of CRP to protect the host of infection and inflammation is thus certainly done first by binding to phosphocholine or other ligands such as phosphoethanolamine, and then by activation of the classical complement pathway via interaction with C1q or phagocytosis via interaction with Fc receptors. | The role of CRP to protect the host of infection and inflammation is thus certainly done first by binding to phosphocholine or other ligands such as phosphoethanolamine, and then by activation of the classical complement pathway via interaction with C1q or phagocytosis via interaction with Fc receptors. | ||
== '''Interaction with C1q''' == | == '''Interaction with C1q and Fcγ receptors''' == | ||
[[Image:C1q.3.jpg]] | [[Image:C1q.3.jpg]] | ||
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The bond of C1 to an activator, as CRP triggers the activation of the classical pathway of the complement. This pathway permits, inter alia, the lysis of infectious agent. An excessive activation of the classical pathway could induce tissue injury in ischemia. Thus, the use of inhibitors that attenuate the activation of the pathway by CRP could be a therapeutic approach in ischemia injury. | The bond of C1 to an activator, as CRP triggers the activation of the classical pathway of the complement. This pathway permits, inter alia, the lysis of infectious agent. An excessive activation of the classical pathway could induce tissue injury in ischemia. Thus, the use of inhibitors that attenuate the activation of the pathway by CRP could be a therapeutic approach in ischemia injury. | ||
Various studies have shown that CRP is able to bind to Fcγ receptor with an affinity comparable to that of IgG. These receptors expressed on hematopoietic cells are able to recognize the Fc portion of IgG. They induce phagocytosis in response to immune system attack. The interaction of CRP with Fcγ receptor suggests that CRP has an important role in the immune system and could explain that CRP concentration increases during the acute phase of the inflammation. | |||
