Sandbox Reserved 819: Difference between revisions
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Furthermore, the bacterioruberin is essential because it plays a structural role for the trimerization of aR2: it mediates interactions between neighbouring monomers. | Furthermore, the bacterioruberin is essential because it plays a structural role for the trimerization of aR2: it mediates interactions between neighbouring monomers. | ||
When the bacterioruberin is bound to the Archaerhodopsin-2, its polyene chain is between the A and B helices of one monomere and the D and E helices of an adjacent one. One end of the bactirouberin is next to the cytoplasmic membrane surfaces and thus is able to interact with the hydrophilic residus of two monomers. The other end of the bacterioruberin protrudes out of the extracellular membrane. | When the bacterioruberin is bound to the Archaerhodopsin-2, its polyene chain is between the A and B helices of one monomere and the D and E helices of an adjacent one. One end of the bactirouberin is next to the cytoplasmic membrane surfaces and thus is able to interact with the hydrophilic residus of two monomers. The other end of the bacterioruberin protrudes out of the extracellular membrane. <ref name="multiple">PMID:18082767</ref> | ||
More precisely, it binds to: the B chain thanks to a hydrogen bond with the <scene name='56/568017/Threonine_112/1'>Threonine 112</scene>, the <scene name='56/568017/Tyrosine/1'>Tyrosine 156</scene> and thanks to an electrostatic bond with the HOH 304; the D chain thanks to a hydrogen bond with the Tyrosine 156; the E chain thanks to a hydrogen bond with the Tyrosine 156. Others bonds exist like van-der-waals bonds [http://www.ebi.ac.uk/pdbe-site/pdbemotif/?tab=boundmolecule&pdb=2z55&ligandCode3letter=22B]. | More precisely, it binds to: the B chain thanks to a hydrogen bond with the <scene name='56/568017/Threonine_112/1'>Threonine 112</scene>, the <scene name='56/568017/Tyrosine/1'>Tyrosine 156</scene> and thanks to an electrostatic bond with the HOH 304; the D chain thanks to a hydrogen bond with the Tyrosine 156; the E chain thanks to a hydrogen bond with the Tyrosine 156. Others bonds exist like van-der-waals bonds [http://www.ebi.ac.uk/pdbe-site/pdbemotif/?tab=boundmolecule&pdb=2z55&ligandCode3letter=22B]. | ||
