Sandbox Reserved 829: Difference between revisions
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Megane Denu (talk | contribs) No edit summary |
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[[Image:Schematic representation of functional domains and phosphorylation sites of PDX-1.jpg|right|580px|thumb|'''Schematic representation of functional domains and phosphorylation sites of PDX-1''']] | [[Image:Schematic representation of functional domains and phosphorylation sites of PDX-1.jpg|right|580px|thumb|'''Schematic representation of functional domains and phosphorylation sites of PDX-1''']] | ||
PDX-1 contains, at the N-terminus, a transactivation domain ( from 1 to 79 amino acids) and the middle region of the protein is composed of a homeodomain (from 146 to 206 amino acids) which is essential for DNA binding and protein-protein interactions. | PDX-1 contains, at the N-terminus, a transactivation domain (from 1 to 79 amino acids) and the middle region of the protein is composed of a homeodomain (from 146 to 206 amino acids) which is essential for DNA binding and protein-protein interactions. | ||
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So, the most stable configuration for the N-terminal arm of Pdx1 consists of Lys 2 inserted in the minor groove and Arg 3 outside of the minor grove contacting the phosphate backbone and Arg 43. | So, the most stable configuration for the N-terminal arm of Pdx1 consists of Lys 2 inserted in the minor groove and Arg 3 outside of the minor grove contacting the phosphate backbone and Arg 43. | ||
