Sandbox Reserved 823: Difference between revisions

Line 1:

==Introduction==<StructureSection load='2NPS' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''>==

==Introduction== <StructureSection load='2NPS' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''>

Important biological processes, such as synaptic transmission and cellular trafficking in Eukaryotes require '''SNARE proteins''' that are thought to play a crucial role in '''membrane fusion'''.<ref> PMID: 11340056 </ref><ref> PMID: 11252968 </ref><ref> PMID: 12600315 </ref><ref> PMID: 12154365 </ref> To connect membranes and allow their fusion, SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) proteins assemble into a '''core-complex of four parallel helices'''.<ref name="anto"> PMID: 11786915 </ref><ref> PMID: 9731768 </ref><ref name="sutton"> PMID: 9759724 </ref> The SNARE complex assembly is mediated by a '''conserved SNARE motif''' consisting of 60-70 amino acids. <ref> PMID: 9096343 </ref> SNAREs can be divided into two categories: the '''v-(vesicle) SNAREs''', which are found in the vesicle membrane and the '''t-(target) SNAREs''', which are anchored in the target membrane.<ref> PMID: 8455717 </ref>

Sandbox Reserved 823: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

Revision as of 17:32, 7 January 2014 view source Camille Roesch (talk \| contribs) 62 edits No edit summary ← Older edit		Revision as of 17:37, 7 January 2014 view source Camille Roesch (talk \| contribs) 62 edits No edit summary Newer edit →
Line 1:		Line 1:
	==Introduction==<StructureSection load='2NPS' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''>==		==Introduction== <StructureSection load='2NPS' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''>

	Important biological processes, such as synaptic transmission and cellular trafficking in Eukaryotes require '''SNARE proteins''' that are thought to play a crucial role in '''membrane fusion'''.<ref> PMID: 11340056 </ref><ref> PMID: 11252968 </ref><ref> PMID: 12600315 </ref><ref> PMID: 12154365 </ref> To connect membranes and allow their fusion, SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) proteins assemble into a '''core-complex of four parallel helices'''.<ref name="anto"> PMID: 11786915 </ref><ref> PMID: 9731768 </ref><ref name="sutton"> PMID: 9759724 </ref> The SNARE complex assembly is mediated by a '''conserved SNARE motif''' consisting of 60-70 amino acids. <ref> PMID: 9096343 </ref> SNAREs can be divided into two categories: the '''v-(vesicle) SNAREs''', which are found in the vesicle membrane and the '''t-(target) SNAREs''', which are anchored in the target membrane.<ref> PMID: 8455717 </ref>		Important biological processes, such as synaptic transmission and cellular trafficking in Eukaryotes require '''SNARE proteins''' that are thought to play a crucial role in '''membrane fusion'''.<ref> PMID: 11340056 </ref><ref> PMID: 11252968 </ref><ref> PMID: 12600315 </ref><ref> PMID: 12154365 </ref> To connect membranes and allow their fusion, SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) proteins assemble into a '''core-complex of four parallel helices'''.<ref name="anto"> PMID: 11786915 </ref><ref> PMID: 9731768 </ref><ref name="sutton"> PMID: 9759724 </ref> The SNARE complex assembly is mediated by a '''conserved SNARE motif''' consisting of 60-70 amino acids. <ref> PMID: 9096343 </ref> SNAREs can be divided into two categories: the '''v-(vesicle) SNAREs''', which are found in the vesicle membrane and the '''t-(target) SNAREs''', which are anchored in the target membrane.<ref> PMID: 8455717 </ref>