Sandbox Reserved 816: Difference between revisions

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'''Internalin K''' is a protein from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogene]

, which is a [http://en.wikipedia.org/wiki/Gram-positive_bacteria Gram-positive bacterium] human pathogen. ~~Its~~ ability to survive in the human intestine and to cross a variety of membranes, including mucosal, intestinal, placental, and blood–brain barriers, allows it to generate illnesses ranging from gastroenteritis in healthy individuals to bacteremia and meningitis in immunocompromised patients, as well as mother-to-child infections. [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogene] can survive in a variety of cell types and proteins of the internalin family have been shown to play a key role in this survival.

, which is a [http://en.wikipedia.org/wiki/Gram-positive_bacteria Gram-positive bacterium] human pathogen. It has the ability to survive in the human intestine and to cross a variety of membranes, including mucosal, intestinal, placental, and blood–brain barriers, allows it to generate illnesses ranging from gastroenteritis in healthy individuals to bacteremia and meningitis in immunocompromised patients, as well as mother-to-child infections. [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogene] can survive in a variety of cell types and proteins of the internalin family have been shown to play a key role in this survival.

'''Internalin K''' is involved in [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogene] ability to escape from autophagy by recruitment of [http://en.wikipedia.org/wiki/Major_vault_protein major vault protein] to the bacterial surface.

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== '''Structure of Internalin K''' ==

'''Internalin K''' is a multi-domain virulence factor. It harbours four domains formed in the shape of '''"bent arm"'''. Domains <scene name='56/568014/D1/1'>D1</scene> and <scene name='56/568014/D2/1'>D2</scene> are related to domains <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene> by an 90° angle.

'''Internalin K''' is a multi-domain virulence factor. It harbours four domains formed in the shape of '''"bent arm"'''. Domains <scene name='56/568014/D1/1'>D1</scene> and <scene name='56/568014/D2/1'>D2</scene> are related to domains <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene> by an 90° angle. The <scene name='56/568014/D1/1'>D1</scene> domain composed of a two-helical cap region and also by the leucine-rich repeats (LRRs). It is stably associated to <scene name='56/568014/D2/1'>D2</scene>

Sandbox Reserved 816: Difference between revisions

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@@ Line 8: / Line 8: @@
 '''Internalin K''' is a protein from [http://en.wikipedia.org/wiki/Listeria_monocytogenes  Listeria monocytogene]
-, which is a [http://en.wikipedia.org/wiki/Gram-positive_bacteria  Gram-positive bacterium] human pathogen.  Its ability to survive in the human intestine and to cross a variety of membranes, including mucosal, intestinal, placental, and blood–brain barriers, allows it to generate illnesses ranging from gastroenteritis in healthy individuals to bacteremia and meningitis in immunocompromised patients, as well as mother-to-child infections. [http://en.wikipedia.org/wiki/Listeria_monocytogenes  Listeria monocytogene] can survive in a variety of cell types and proteins of the internalin family have been shown to play a key role in this survival.
+, which is a [http://en.wikipedia.org/wiki/Gram-positive_bacteria  Gram-positive bacterium] human pathogen.  It has the ability to survive in the human intestine and to cross a variety of membranes, including mucosal, intestinal, placental, and blood–brain barriers, allows it to generate illnesses ranging from gastroenteritis in healthy individuals to bacteremia and meningitis in immunocompromised patients, as well as mother-to-child infections. [http://en.wikipedia.org/wiki/Listeria_monocytogenes  Listeria monocytogene] can survive in a variety of cell types and proteins of the internalin family have been shown to play a key role in this survival.
 '''Internalin K''' is involved in [http://en.wikipedia.org/wiki/Listeria_monocytogenes  Listeria monocytogene] ability to escape from autophagy by recruitment of [http://en.wikipedia.org/wiki/Major_vault_protein major vault protein] to the bacterial surface.
@@ Line 27: / Line 27: @@
 == '''Structure of Internalin K''' ==
-'''Internalin K''' is a multi-domain virulence factor. It harbours four domains formed in the shape of '''"bent arm"'''. Domains <scene name='56/568014/D1/1'>D1</scene> and <scene name='56/568014/D2/1'>D2</scene> are related to domains <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene> by an 90° angle.
+'''Internalin K''' is a multi-domain virulence factor. It harbours four domains formed in the shape of '''"bent arm"'''. Domains <scene name='56/568014/D1/1'>D1</scene> and <scene name='56/568014/D2/1'>D2</scene> are related to domains <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene> by an 90° angle. The <scene name='56/568014/D1/1'>D1</scene> domain composed of a two-helical cap region and also by the leucine-rich repeats (LRRs). It is stably associated to <scene name='56/568014/D2/1'>D2</scene>