Sandbox Reserved 816: Difference between revisions

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== '''Structure of Internalin K''' ==

'''Internalin K''' is a multi-domain virulence factor. It harbours four domains formed in the shape of '''"bent arm"'''. Domains <scene name='56/568014/D1/1'>D1</scene> and <scene name='56/568014/D2/1'>D2</scene> are related to domains <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene> by an 90° angle. The <scene name='56/568014/D1/1'>D1</scene> domain composed of a two-helical cap region and also by the leucine-rich repeats (LRRs). It is stably associated to <scene name='56/568014/D2/1'>D2</scene>

'''Internalin K''' is a multi-domain virulence factor. It harbours four domains formed in the shape of '''"bent arm"'''.

Domains <scene name='56/568014/D1/1'>D1</scene> and <scene name='56/568014/D2/1'>D2</scene> are related to domains <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene> by an 90° angle.

The <scene name='56/568014/D1/1'>D1</scene> domain composed of a two-helical cap region and also by the leucine-rich repeats (LRRs). It is stably associated to <scene name='56/568014/D2/1'>D2</scene>.

<scene name='56/568014/D2/1'>D2</scene> has few contacts with <scene name='56/568014/D3/1'>D3</scene> which improves the flexibility required by '''Internalin K''' to bind to its partner while remaining associated to the surface of the bacterium.

The association of <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D2/1'>D2</scene> domains represent the "elbow" region. It means the recognition of major vault protein domain.

Domains <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene>, located in tandem and related to each other by an approximate 2-fold axis, both fold into compact structures composed of three antiparallel strands packed against two small helices. There are [http://en.wikipedia.org/wiki/Immunoglobulin_superfamily immunoglobulin]-like domain.

<scene name='56/568014/D1/1'>D1</scene> and <scene name='56/568014/D2/1'>D2</scene> are involved in binding to protein partners while <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene> most probably serve as pedestals. The flexibility between domains of its elongated structure may play a key role in this complex function.

Sandbox Reserved 816: Difference between revisions

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@@ Line 27: / Line 27: @@
 == '''Structure of Internalin K''' ==
-'''Internalin K''' is a multi-domain virulence factor. It harbours four domains formed in the shape of '''"bent arm"'''. Domains <scene name='56/568014/D1/1'>D1</scene> and <scene name='56/568014/D2/1'>D2</scene> are related to domains <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene> by an 90° angle. The <scene name='56/568014/D1/1'>D1</scene> domain composed of a two-helical cap region and also by the leucine-rich repeats (LRRs). It is stably associated to <scene name='56/568014/D2/1'>D2</scene>
+'''Internalin K''' is a multi-domain virulence factor. It harbours four domains formed in the shape of '''"bent arm"'''.
+Domains <scene name='56/568014/D1/1'>D1</scene> and <scene name='56/568014/D2/1'>D2</scene> are related to domains <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene> by an 90° angle.
+The <scene name='56/568014/D1/1'>D1</scene> domain composed of a two-helical cap region and also by the leucine-rich repeats (LRRs). It is stably associated to <scene name='56/568014/D2/1'>D2</scene>.
+<scene name='56/568014/D2/1'>D2</scene> has few contacts with <scene name='56/568014/D3/1'>D3</scene> which improves the flexibility required by '''Internalin K''' to bind to its partner while remaining associated to the surface of the bacterium.
+The association of <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D2/1'>D2</scene> domains represent the "elbow" region. It means the recognition of major vault protein domain.
+Domains <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene>, located in tandem and related to each other by an approximate 2-fold axis, both fold into compact structures composed of three antiparallel strands packed against two small helices. There are [http://en.wikipedia.org/wiki/Immunoglobulin_superfamily immunoglobulin]-like domain.
+<scene name='56/568014/D1/1'>D1</scene> and <scene name='56/568014/D2/1'>D2</scene> are involved in binding to protein partners while <scene name='56/568014/D3/1'>D3</scene> and <scene name='56/568014/D4/1'>D4</scene> most probably serve as pedestals. The flexibility between domains of its elongated structure may play a key role in this complex function.