Sandbox Reserved 825: Difference between revisions
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The surface structure reveals two main interaction sites, a shallow <scene name='56/568023/Hydrophobic_pocket/1'>hydrophobic patch</scene> made up of helix 1 and helix 4 | The surface structure reveals two main interaction sites, a shallow <scene name='56/568023/Hydrophobic_pocket/1'>hydrophobic patch</scene> made up of helix 1 and helix 4 | ||
which is responsible for the binding of rapamycin and a <scene name='56/568023/Deep_cleft_helix_2_and_3/ | which is responsible for the binding of rapamycin and a <scene name='56/568023/Deep_cleft_helix_2_and_3/8'>deep cleft</scene> between helix 2 and helix 3. This cleft contains | ||
charged and hydrophobic residues and is expected to function as a binding site for small molecules to regulate | charged and hydrophobic residues and is expected to function as a binding site for small molecules to regulate | ||
mTOR activity. | mTOR activity. | ||
