Sandbox Reserved 818: Difference between revisions

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{{Sandbox_Reserved_ESBS}}
{{Sandbox_Reserved_ESBS}}
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{{STRUCTURE_1prt|  PDB=1prt  |  SCENE= | caption="Pertussis Toxin produced and secreted by ''Bordetella pertussis''" }}


[[Image:1prt.png|left|200px]]
[[Image:1prt.png|left|200px]]
 
'''Pertussis Toxin (PTX)''' is a toxin produced and secreted by the bacteria ''Bordetella pertussis'', also known as the [http://en.wikipedia.org/wiki/Whooping_cough whooping cough] agent.
{{STRUCTURE_1prt|  PDB=1prt  |  SCENE=  }}
It is a complex soluble bacterial [[:wiktionary:holotoxin|Holotoxin]], composed of 5 subuntits (named S1 to S5 according to their decreasing molecular weights), arranged in an A-B structure. The A part contains the enzymatically active S1 subunit, which catalyzes ADP-ribosylation of α subunit of [http://en.wikipedia.org/wiki/G_protein trimeric G proteins], thereby disturbing major metabolic functions of the target cells, leading to a variety of biological activities.
 
The B oligomer is composed by 1S2:1S3:2S4:1S5 and is responsible for binding of the toxin to target cell receptors and for intracellular traficking.
===PERTUSSIS TOXIN===
This toxin is a major virulence factor of ''B. pertussis'' and is a component of vaccines against [http://en.wikipedia.org/wiki/Whooping_cough whooping cough].
 
 
 
==About this Structure==
[[1prt]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. The September 2005 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Cholera Toxin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2005_9 10.2210/rcsb_pdb/mom_2005_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRT OCA].
 
 
==Introduction==
Pertussis Toxin (PTX) is a toxin produced and secreted by the bacteria ''Bordetella pertussis'', also known as the whooping cough agent.
It is a complex soluble bacterial [[:wiktionary:holotoxin|Holotoxin]], composed of 5 subuntits (named S1 to S5 according to their decreasing molecular weights), arranged in an A-B structure. The A part contains the enzymatically active S1 subunit, which catalyzes ADP-ribosylation of α subunit of [[:wikipedia:G protein|trimeric G proteins]]
Adding an introduction <br />
3-7 sentences about what the protein or topic is and why it is important <br />
first sentence should contain the name of the topic and it should be an interwiki link (so on the Hemoglobin page, you might start by writing "[[Hemoglobin]] is the protein...") <br />
touch on medical relevance if there is any <br />
absolutely no external links


==Binding of pertussis toxin to its cellular targets==
==Binding of pertussis toxin to its cellular targets==
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