2veu: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
The structure-based design and synthesis of isothiazolidinone (IZD) | The structure-based design and synthesis of isothiazolidinone (IZD) inhibitors of PTP1B containing imidazoles and imidazolines and their modification to interact with the B site of PTP1B are described here. The X-ray crystal structures of 3I and 4I complexed with PTP1B were solved and revealed the inhibitors are interacting extensively with the B site of the enzyme. | ||
==Disease== | ==Disease== | ||
| Line 17: | Line 17: | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Ala, P | [[Category: Ala, P J.]] | ||
[[Category: Bostrom, L.]] | [[Category: Bostrom, L.]] | ||
[[Category: Bower, M | [[Category: Bower, M J.]] | ||
[[Category: Burn, T | [[Category: Burn, T C.]] | ||
[[Category: Combs, A | [[Category: Combs, A P.]] | ||
[[Category: Douty, B.]] | [[Category: Douty, B.]] | ||
[[Category: Gonneville, L.]] | [[Category: Gonneville, L.]] | ||
[[Category: Klabe, R.]] | [[Category: Klabe, R.]] | ||
[[Category: Liu, P | [[Category: Liu, P C.C.]] | ||
[[Category: Pruitt, J.]] | [[Category: Pruitt, J.]] | ||
[[Category: Wayland, B.]] | [[Category: Wayland, B.]] | ||
[[Category: Wei, M.]] | [[Category: Wei, M.]] | ||
[[Category: Wynn, R.]] | [[Category: Wynn, R.]] | ||
[[Category: Yue, E | [[Category: Yue, E W.]] | ||
[[Category: IZ1]] | [[Category: IZ1]] | ||
[[Category: acetylation]] | [[Category: acetylation]] | ||
| Line 42: | Line 42: | ||
[[Category: protein phosphatase]] | [[Category: protein phosphatase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:55:20 2008'' | ||
