4lez: Difference between revisions
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{{STRUCTURE_4lez| PDB=4lez | SCENE= }} | {{STRUCTURE_4lez| PDB=4lez | SCENE= }} | ||
===Structure of mouse cGAS bound to an 18bp DNA and cGAS product=== | ===Structure of mouse cGAS bound to an 18bp DNA and cGAS product=== | ||
{{ABSTRACT_PUBMED_24332030}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4lez]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEZ OCA]. | [[4lez]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEZ OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:024332030</ref><references group="xtra"/><references/> | |||
[[Category: Li, P.]] | [[Category: Li, P.]] | ||
[[Category: Dna sensor]] | [[Category: Dna sensor]] | ||
[[Category: Ntase]] | [[Category: Ntase]] | ||
[[Category: Transferase-dna complex]] | [[Category: Transferase-dna complex]] | ||
Revision as of 08:18, 8 January 2014
Structure of mouse cGAS bound to an 18bp DNA and cGAS product
Template:ABSTRACT PUBMED 24332030
Function
[CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
About this Structure
4lez is a 6 chain structure. Full crystallographic information is available from OCA.
Reference
- Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, Zuo X, Kao CC, Herr AB, Li P. Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization. Immunity. 2013 Dec 12;39(6):1019-31. doi: 10.1016/j.immuni.2013.10.019. PMID:24332030 doi:https://dx.doi.org/10.1016/j.immuni.2013.10.019
