4lev: Difference between revisions
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{{STRUCTURE_4lev| PDB=4lev | SCENE= }} | {{STRUCTURE_4lev| PDB=4lev | SCENE= }} | ||
===Structure of human cGAS=== | ===Structure of human cGAS=== | ||
{{ABSTRACT_PUBMED_24332030}} | |||
==Function== | ==Function== | ||
| Line 9: | Line 10: | ||
==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:024332030</ref><references group="xtra"/><references/> | ||
[[Category: Li, P.]] | [[Category: Li, P.]] | ||
[[Category: Dna sensor]] | [[Category: Dna sensor]] | ||
[[Category: Ntase]] | [[Category: Ntase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 08:27, 8 January 2014
Structure of human cGAS
Template:ABSTRACT PUBMED 24332030
Function
[CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.[1] [2]
About this Structure
4lev is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, Zuo X, Kao CC, Herr AB, Li P. Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization. Immunity. 2013 Dec 12;39(6):1019-31. doi: 10.1016/j.immuni.2013.10.019. PMID:24332030 doi:https://dx.doi.org/10.1016/j.immuni.2013.10.019
- ↑ Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011 Apr 28;472(7344):481-5. doi: 10.1038/nature09907. Epub 2011 Apr 10. PMID:21478870 doi:10.1038/nature09907
- ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458
