4cdk: Difference between revisions
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{{STRUCTURE_4cdk| PDB=4cdk | SCENE= }} | |||
===Structure of ZNRF3-RSPO1=== | |||
{{ABSTRACT_PUBMED_24349440}} | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Palmoplantar keratoderma - XX sex reversal - predisposition to squamous cell carcinoma. Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:[http://omim.org/entry/610644 610644]]: A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Note=The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref> [[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.<ref>PMID:16109882</ref> <ref>PMID:22575959</ref> | |||
==About this Structure== | |||
[[4cdk]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CDK OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024349440</ref><references group="xtra"/><references/> | |||
[[Category: Clevers, H.]] | |||
[[Category: Forneris, F.]] | |||
[[Category: Granneman, J C.M.]] | |||
[[Category: Gros, P.]] | |||
[[Category: Lau, W de.]] | |||
[[Category: Madoori, P K.]] | |||
[[Category: Peng, W C.]] | |||
[[Category: Adult stem cell]] | |||
[[Category: E3 ligase]] | |||
[[Category: Lgr5]] | |||
[[Category: Ligase]] | |||
[[Category: Protease-associated domain]] | |||
[[Category: R-spondin]] | |||
[[Category: Wnt signaling]] | |||
[[Category: Zinc ring finger]] | |||
