4mi5: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the EZH2 SET domain===

The entry ~~4mi5 is ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/EZH2_HUMAN EZH2_HUMAN]] Weaver syndrome. The disease is caused by mutations affecting the gene represented in this entry.

~~Authors~~: ~~Antonysamy, S~~.~~, Condon, B~~.~~, Druzina, Z~~., ~~Bonanno~~, J., ~~Gheyi, T.~~, ~~Macewan~~, I., ~~Zhang~~, A., ~~Ashok, S~~., ~~Russell, M.~~, ~~Luz~~, J.G.

==Function==

[[http://www.uniprot.org/uniprot/EZH2_HUMAN EZH2_HUMAN]] Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA.<ref>PMID:14532106</ref> <ref>PMID:15385962</ref> <ref>PMID:15231737</ref> <ref>PMID:15225548</ref> <ref>PMID:16179254</ref> <ref>PMID:16618801</ref> <ref>PMID:16357870</ref> <ref>PMID:16936726</ref> <ref>PMID:17210787</ref> <ref>PMID:17344414</ref> <ref>PMID:19026781</ref> <ref>PMID:18285464</ref> <ref>PMID:20935635</ref> <ref>PMID:23063525</ref>

~~Description~~: ~~Crystal structure of the EZH2 SET domain~~

==About this Structure==

[[4mi5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MI5 OCA].

==Reference==

[[Category: Histone-lysine N-methyltransferase]]

[[Category: Antonysamy, S.]]

[[Category: Ashok, S.]]

[[Category: Bonanno, J.]]

[[Category: Condon, B.]]

[[Category: Druzina, Z.]]

[[Category: Gheyi, T.]]

[[Category: Luz, J G.]]

[[Category: Macewan, I.]]

[[Category: Russell, M.]]

[[Category: Zhang, A.]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4mi5|  PDB=4mi5  |  SCENE=  }}
+===Crystal structure of the EZH2 SET domain===
+{{ABSTRACT_PUBMED_24367637}}
-The entry 4mi5 is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/EZH2_HUMAN EZH2_HUMAN]] Weaver syndrome. The disease is caused by mutations affecting the gene represented in this entry.
-Authors: Antonysamy, S., Condon, B., Druzina, Z., Bonanno, J., Gheyi, T., Macewan, I., Zhang, A., Ashok, S., Russell, M., Luz, J.G.
+==Function==
+[[http://www.uniprot.org/uniprot/EZH2_HUMAN EZH2_HUMAN]] Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA.<ref>PMID:14532106</ref> <ref>PMID:15385962</ref> <ref>PMID:15231737</ref> <ref>PMID:15225548</ref> <ref>PMID:16179254</ref> <ref>PMID:16618801</ref> <ref>PMID:16357870</ref> <ref>PMID:16936726</ref> <ref>PMID:17210787</ref> <ref>PMID:17344414</ref> <ref>PMID:19026781</ref> <ref>PMID:18285464</ref> <ref>PMID:20935635</ref> <ref>PMID:23063525</ref>
-Description: Crystal structure of the EZH2 SET domain
+==About this Structure==
+[[4mi5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MI5 OCA].
+==Reference==
+<ref group="xtra">PMID:024367637</ref><references group="xtra"/><references/>
+[[Category: Histone-lysine N-methyltransferase]]
+[[Category: Antonysamy, S.]]
+[[Category: Ashok, S.]]
+[[Category: Bonanno, J.]]
+[[Category: Condon, B.]]
+[[Category: Druzina, Z.]]
+[[Category: Gheyi, T.]]
+[[Category: Luz, J G.]]
+[[Category: Macewan, I.]]
+[[Category: Russell, M.]]
+[[Category: Zhang, A.]]
+[[Category: Transferase]]