4ccg: Difference between revisions

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~~'''Unreleased structure'''~~

===Structure of an E2-E3 complex===

The entry ~~4ccg is ON HOLD until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.

~~Authors~~: ~~Hodson~~, C., ~~Purkiss~~, A., ~~Walden~~, H.

==Function==

[[http://www.uniprot.org/uniprot/UBE2T_HUMAN UBE2T_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.<ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19887602</ref> <ref>PMID:19589784</ref> <ref>PMID:20061386</ref> [[http://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.<ref>PMID:12973351</ref> <ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19589784</ref>

~~Description~~: ~~Structure of an E2~~-~~E3 complex~~

==About this Structure==

[[4ccg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CCG OCA].

==Reference==

[[Category: Hodson, C.]]

[[Category: Purkiss, A.]]

[[Category: Walden, H.]]

[[Category: Ligase]]

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-'''Unreleased structure'''
+{{STRUCTURE_4ccg|  PDB=4ccg  |  SCENE=  }}
+===Structure of an E2-E3 complex===
-The entry 4ccg is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
-Authors: Hodson, C., Purkiss, A., Walden, H.
+==Function==
+[[http://www.uniprot.org/uniprot/UBE2T_HUMAN UBE2T_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.<ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19887602</ref> <ref>PMID:19589784</ref> <ref>PMID:20061386</ref>  [[http://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.<ref>PMID:12973351</ref> <ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19589784</ref>
-Description: Structure of an E2-E3 complex
+==About this Structure==
+[[4ccg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CCG OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Hodson, C.]]
+[[Category: Purkiss, A.]]
+[[Category: Walden, H.]]
+[[Category: Ligase]]