4n7f: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of 3rd WW domain of human Nedd4-1===

~~The entry 4n7f~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/NEDD4_HUMAN NEDD4_HUMAN]] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.<ref>PMID:17218260</ref> <ref>PMID:18562292</ref> <ref>PMID:20086093</ref> <ref>PMID:21765395</ref> <ref>PMID:21399620</ref>

~~Authors~~: ~~Qi, S., O'Hayre, M~~.~~, Gutkind, J~~.S.~~, Hurley, J~~.

==About this Structure==

[[4n7f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N7F OCA].

~~Description~~: ~~Crystal structure of 3rd WW~~ domain ~~of human Nedd4-1~~

==Reference==

[[Category: Gutkind, J S.]]

[[Category: Hayre, M O.]]

[[Category: Hurley, J.]]

[[Category: Qi, S.]]

[[Category: Beta sheet]]

[[Category: Cytosolic]]

[[Category: Proline rich region]]

[[Category: Protein binding]]

[[Category: Target binding]]

[[Category: Ww domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4n7f|  PDB=4n7f  |  SCENE=  }}
+===Crystal structure of 3rd WW domain of human Nedd4-1===
-The entry 4n7f is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/NEDD4_HUMAN NEDD4_HUMAN]] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.<ref>PMID:17218260</ref> <ref>PMID:18562292</ref> <ref>PMID:20086093</ref> <ref>PMID:21765395</ref> <ref>PMID:21399620</ref>
-Authors: Qi, S., O'Hayre, M., Gutkind, J.S., Hurley, J.
+==About this Structure==
+[[4n7f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N7F OCA].
-Description: Crystal structure of 3rd WW domain of human Nedd4-1
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Gutkind, J S.]]
+[[Category: Hayre, M O.]]
+[[Category: Hurley, J.]]
+[[Category: Qi, S.]]
+[[Category: Beta sheet]]
+[[Category: Cytosolic]]
+[[Category: Proline rich region]]
+[[Category: Protein binding]]
+[[Category: Target binding]]
+[[Category: Ww domain]]