Sandbox Reserved 818: Difference between revisions
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{{STRUCTURE_1prt| PDB=1prt | SCENE= | caption="Pertussis Toxin produced and secreted by ''Bordetella pertussis''" }} | {{STRUCTURE_1prt| PDB=1prt | SCENE= | caption="Pertussis Toxin produced and secreted by ''Bordetella pertussis''" }} | ||
[[Image: | [[Image:Pertussis_toxin_complex.png|thumb|left|350px|Cartoon representation of the molecular structure of pertussis toxin. ]] | ||
'''Pertussis Toxin (PTX)''' is a toxin produced and secreted by the bacteria ''Bordetella pertussis'', also known as the [http://en.wikipedia.org/wiki/Whooping_cough whooping cough] agent. | '''Pertussis Toxin (PTX)''' is a toxin produced and secreted by the bacteria ''Bordetella pertussis'', also known as the [http://en.wikipedia.org/wiki/Whooping_cough whooping cough] agent. | ||
It is a complex soluble bacterial [[:wiktionary:holotoxin|Holotoxin]], composed of 5 subuntits (named S1 to S5 according to their decreasing molecular weights), arranged in an A-B structure. The A part contains the enzymatically active S1 subunit, which catalyzes ADP-ribosylation of α subunit of [http://en.wikipedia.org/wiki/G_protein trimeric G proteins], thereby disturbing major metabolic functions of the target cells, leading to a variety of biological activities. | It is a complex soluble bacterial [[:wiktionary:holotoxin|Holotoxin]], composed of 5 subuntits (named S1 to S5 according to their decreasing molecular weights), arranged in an A-B structure. The A part contains the enzymatically active S1 subunit, which catalyzes ADP-ribosylation of α subunit of [http://en.wikipedia.org/wiki/G_protein trimeric G proteins], thereby disturbing major metabolic functions of the target cells, leading to a variety of biological activities. | ||
