Sandbox Reserved 818: Difference between revisions

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cAMP is primary in many biological processes that's why its accumulation leads to the disruption of cellular metabolism and pathological events, according to infected cells. <br />
cAMP is primary in many biological processes that's why its accumulation leads to the disruption of cellular metabolism and pathological events, according to infected cells. <br />
Thus biological activities of PTX are especially ''histamine sensitization'', ''islet activation'' and ''lymphocytosis''.
Thus biological activities of PTX are especially ''histamine sensitization'', ''islet activation'' and ''lymphocytosis''.
==Structural Informations allow to produce efficient vaccine==
Cristal structure provided insight into the pathogenic mechanisms of PTX. Informations about the tertiary structure of the active site a good basis for elimination of the catalytic activity in recombinant molecules for vaccine use.
For example, one highly detoxified PTX analog contains two alterations in the S1 subunit (Arg9 to Lys; Glu129 to Gly), each of which is able to totally abolish the enzymativ activity of the toxin. This molecule already belongs to the new-generation of pertussis vaccines
<ref name="Karzon90">
Edwards, K. M., & Karzon, D. T. (1990). Pertussis vaccines. Pediatric clinics of North America, 37(3), 549.
<\ref>.


==See Also==
==See Also==
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==Proteopedia Page Contributors and Editors==
==Proteopedia Page Contributors and Editors==
[[User:Paul Giroud|Paul Giroud]] 01:23, 9 January 2014 (IST)
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