Sandbox Reserved 817: Difference between revisions

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In mouse and human brain, native BACE1 occurs as a dimer. Dimerization is dependent on membrane attachment and increases BACE1 affinity and turnover rate toward APP-like peptides when compared to the monomeric, soluble form. The different enzymatic properties of monomeric and dimeric BACE1 need to be considered in future drug screening and development processes. <ref name="four">PMID:22363289</ref>  
In mouse and human brain, native BACE1 is found as a dimer. Dimerization is dependent on membrane attachment and increases BACE1 affinity and turnover rate toward APP-like peptides when compared to the monomeric, soluble form. The different enzymatic properties of monomeric and dimeric BACE1 need to be considered in future drug screening and development processes. <ref name="four">PMID:22363289</ref>  




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