Sandbox Reserved 818: Difference between revisions
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==Structural informations allow to produce efficient vaccine== | ==Structural informations allow to produce efficient vaccine== | ||
Crystal structure provided insight into the pathogenic mechanisms of PTX. Informations about the tertiary structure of the active site is a good basis for elimination of the catalytic activity in recombinant molecules for vaccine use. | |||
For example, one highly detoxified PTX analog contains two alterations in the S1 subunit (Arg9 to Lys; Glu129 to Gly), each of which is able to totally abolish the enzymativ activity of the toxin. This molecule already belongs to the new-generation of pertussis vaccines <ref name="Karzon90">PMID:2190139</ref>. | For example, one highly detoxified PTX analog contains two alterations in the S1 subunit (Arg9 to Lys; Glu129 to Gly), each of which is able to totally abolish the enzymativ activity of the toxin. This molecule already belongs to the new-generation of pertussis vaccines <ref name="Karzon90">PMID:2190139</ref>. | ||
==See Also== | ==See Also== | ||
