Sandbox Reserved 815: Difference between revisions
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='''3HAF DOMAIN'''= | |||
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{{Sandbox-reserved-ESBS}} | {{Sandbox-reserved-ESBS}} | ||
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[[Image:54.jpg|right|550px|thumb|'''3HAF Domain''']] | [[Image:54.jpg|right|550px|thumb|'''3HAF Domain''']] | ||
=Introduction= | |||
'''=Introduction=''' | |||
[[Image:3haf bio r 500.jpg|left|220px|thumb|'''3HAF Domain-Dimer''']] | [[Image:3haf bio r 500.jpg|left|220px|thumb|'''3HAF Domain-Dimer''']] | ||
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=Structure of 3HAF domain of Human Prion= | |||
'''=Structure of 3HAF domain of Human Prion=''' | |||
The 3HAF structure results from a work leaded by Lee S. in 2010, in which they have characterized seven variants of the human prion. The structure was determined by XRAY diffraction in a 2.26-Angstrom resolution. | The 3HAF structure results from a work leaded by Lee S. in 2010, in which they have characterized seven variants of the human prion. The structure was determined by XRAY diffraction in a 2.26-Angstrom resolution. | ||
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= Ligand and interactions = | '''=Ligand and interactions =''' | ||
[[Image:Ligand cl.jpg|left|200px||thumb|'''Bond between 3HAF domain and the Ligand Cd2+''']] | [[Image:Ligand cl.jpg|left|200px||thumb|'''Bond between 3HAF domain and the Ligand Cd2+''']] | ||
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= Repercussion of the M129/V129 polymorphism = | '''=Repercussion of the M129/V129 polymorphism =''' | ||
[[Image:Yes.jpg|left|400px||thumb|'''Polymorphism of beta sheet interface''']] | [[Image:Yes.jpg|left|400px||thumb|'''Polymorphism of beta sheet interface''']] | ||
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=See Also= | '''=See Also=''' | ||
*[[Prion|Prion]] | *[[Prion|Prion]] | ||
*[http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=3haf&template=main.html PDBSum] | *[http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=3haf&template=main.html PDBSum] | ||
*[http://www.ebi.ac.uk/pdbe-srv/view/entry/3haf/summary.html EMBISum] | *[http://www.ebi.ac.uk/pdbe-srv/view/entry/3haf/summary.html EMBISum] | ||
=Reference= | '''=Reference=''' | ||
<ref group="xtra">PMID:019927125</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:019927125</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
