4au7: Difference between revisions
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{{STRUCTURE_4au7| PDB=4au7 | SCENE= }} | {{STRUCTURE_4au7| PDB=4au7 | SCENE= }} | ||
===The structure of the Suv4-20h2 ternary complex with histone H4=== | ===The structure of the Suv4-20h2 ternary complex with histone H4=== | ||
{{ABSTRACT_PUBMED_24049080}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SV422_MOUSE SV422_MOUSE]] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).<ref>PMID:15145825</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4au7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4au7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AU7 OCA]. | ||
==See Also== | |||
*[[Histone methyltransferase|Histone methyltransferase]] | |||
==Reference== | |||
<ref group="xtra">PMID:024049080</ref><references group="xtra"/><references/> | |||
[[Category: Histone-lysine N-methyltransferase]] | [[Category: Histone-lysine N-methyltransferase]] | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Cronin, N B.]] | [[Category: Cronin, N B.]] | ||
[[Category: Southall, S M.]] | [[Category: Southall, S M.]] | ||
