3b0i: Difference between revisions
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{{STRUCTURE_3b0i| PDB=3b0i | SCENE= }} | {{STRUCTURE_3b0i| PDB=3b0i | SCENE= }} | ||
===Crystal structure of recombinant human alpha lactalbumin=== | ===Crystal structure of recombinant human alpha lactalbumin=== | ||
{{ABSTRACT_PUBMED_23155056}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LALBA_HUMAN LALBA_HUMAN]] Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. | |||
==About this Structure== | ==About this Structure== | ||
[[3b0i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3b0i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0I OCA]. | ||
[[Category: | |||
==Reference== | |||
<ref group="xtra">PMID:023155056</ref><references group="xtra"/><references/> | |||
[[Category: Human]] | |||
[[Category: Makabe, K.]] | [[Category: Makabe, K.]] | ||
[[Category: Calcium binding protein]] | [[Category: Calcium binding protein]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
Revision as of 07:16, 15 January 2014
Crystal structure of recombinant human alpha lactalbumin
Template:ABSTRACT PUBMED 23155056
Function
[LALBA_HUMAN] Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
About this Structure
3b0i is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Makabe K, Nakamura T, Kuwajima K. Structural insights into the stability perturbations induced by N-terminal variation in human and goat alpha-lactalbumin. Protein Eng Des Sel. 2013 Feb;26(2):165-70. doi: 10.1093/protein/gzs093. Epub, 2012 Nov 14. PMID:23155056 doi:https://dx.doi.org/10.1093/protein/gzs093
