4nen: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===An internal ligand-bound, metastable state of a leukocyte integrin, aXb2===

~~The~~ entry ~~4nen is ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>

~~Authors~~: ~~Sen~~, M.~~, Yuki, K~~.~~, Springer, T~~.A.

==Function==

[[http://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>

~~Description~~: ~~An internal ligand~~-~~bound~~, ~~metastable state of a leukocyte integrin~~, ~~aXb2~~

==About this Structure==

[[4nen]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEN OCA].

==Reference==

[[Category: Sen, M.]]

[[Category: Springer, T A.]]

[[Category: Yuki, K.]]

[[Category: Cell adhesion]]

[[Category: Complement receptor]]

[[Category: Denaturated protein]]

[[Category: Fibrinogen]]

[[Category: Heparin]]

[[Category: Ic3b]]

[[Category: Icam]]

[[Category: Membrane]]

[[Category: N-linked glycosylation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nen|  PDB=4nen  |  SCENE=  }}
+===An internal ligand-bound, metastable state of a leukocyte integrin, aXb2===
+{{ABSTRACT_PUBMED_24385486}}
-The entry 4nen is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>
-Authors: Sen, M., Yuki, K., Springer, T.A.
+==Function==
+[[http://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>
-Description: An internal ligand-bound, metastable state of a leukocyte integrin, aXb2
+==About this Structure==
+[[4nen]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEN OCA].
+==Reference==
+<ref group="xtra">PMID:024385486</ref><references group="xtra"/><references/>
+[[Category: Sen, M.]]
+[[Category: Springer, T A.]]
+[[Category: Yuki, K.]]
+[[Category: Cell adhesion]]
+[[Category: Complement receptor]]
+[[Category: Denaturated protein]]
+[[Category: Fibrinogen]]
+[[Category: Heparin]]
+[[Category: Ic3b]]
+[[Category: Icam]]
+[[Category: Membrane]]
+[[Category: N-linked glycosylation]]