4l9c: Difference between revisions
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{{STRUCTURE_4l9c| PDB=4l9c | SCENE= }} | |||
===Crystal structure of the FP domain of human F-box protein Fbxo7 (native)=== | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN]] Parkinsonian-pyramidal syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN]] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.<ref>PMID:15145941</ref> <ref>PMID:16510124</ref> | |||
==About this Structure== | |||
[[4l9c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9C OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Du,Z.]] | |||
[[Category: Huang,X.]] | |||
[[Category: Shang,J.]] | |||
[[Category: Wang,G.]] | |||
[[Category: Yang,Y.]] | |||
[[Category: Alpha/beta fold]] | |||
[[Category: Protein binding]] | |||
Revision as of 08:24, 15 January 2014
Crystal structure of the FP domain of human F-box protein Fbxo7 (native)
Disease
[FBX7_HUMAN] Parkinsonian-pyramidal syndrome. The disease is caused by mutations affecting the gene represented in this entry.
Function
[FBX7_HUMAN] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.[1] [2]
About this Structure
4l9c is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Hsu JM, Lee YC, Yu CT, Huang CY. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. J Biol Chem. 2004 Jul 30;279(31):32592-602. Epub 2004 May 15. PMID:15145941 doi:https://dx.doi.org/10.1074/jbc.M404950200
- ↑ Chang YF, Cheng CM, Chang LK, Jong YJ, Yuo CY. The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1022-6. Epub 2006 Feb 21. PMID:16510124 doi:https://dx.doi.org/10.1016/j.bbrc.2006.02.061
