1h23: Difference between revisions
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{{STRUCTURE_1h23| PDB=1h23 | SCENE= }} | {{STRUCTURE_1h23| PDB=1h23 | SCENE= }} | ||
=== | ===Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(12)-hupyridone at 2.15A resolution=== | ||
{{ABSTRACT_PUBMED_12517147}} | {{ABSTRACT_PUBMED_12517147}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012517147</ref>< | <ref group="xtra">PMID:012517147</ref><references group="xtra"/><references/> | ||
[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
[[Category: Torpedo californica]] | [[Category: Torpedo californica]] | ||
Revision as of 05:45, 22 January 2014
Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(12)-hupyridone at 2.15A resolution
Template:ABSTRACT PUBMED 12517147
Function
[ACES_TORCA] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
About this Structure
1h23 is a 1 chain structure with sequence from Torpedo californica. Full crystallographic information is available from OCA.
See Also
- AChE bivalent inhibitors
- Acetylcholinesterase
- Torpedo Californica Acetylcholinesterase in complex with an (R)-Tacrine-(10)-Hupyridone inhibitor
- User:Dawn M. Wong
Reference
- Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity. J Am Chem Soc. 2003 Jan 15;125(2):363-73. PMID:12517147 doi:https://dx.doi.org/10.1021/ja021111w
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Acetylcholinesterase
- Torpedo californica
- Carlier, P R.
- Greenblatt, H M.
- Han, Y F.
- Pang, Y P.
- Silman, I.
- Sussman, J L.
- Wong, D M.
- Alzheimer's disease
- Bivalent ligand
- Dual-site binding
- Glycoprotein
- Gpi-anchor neurotransmitter degradation
- Huperzine some
- Hydrolase
- Inhibitor
- Membrane
- Muscle
- Nerve
- Neurotransmitter cleavage
- Serine esterase synapse
- Serine hydrolase
