3pl7: Difference between revisions
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{{STRUCTURE_3pl7| PDB=3pl7 | SCENE= }} | {{STRUCTURE_3pl7| PDB=3pl7 | SCENE= }} | ||
===Crystal structure of Bcl-xL in complex with the BaxBH3 domain=== | ===Crystal structure of Bcl-xL in complex with the BaxBH3 domain=== | ||
{{ABSTRACT_PUBMED_21199865}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3pl7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3pl7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PL7 OCA]. | ||
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021199865</ref><references group="xtra"/> | <ref group="xtra">PMID:021199865</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Colman, P M.]] | [[Category: Colman, P M.]] | ||
[[Category: Czabotar, P E.]] | [[Category: Czabotar, P E.]] | ||
