3pk1: Difference between revisions

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~~[[Image:3pk1.png|left|200px]]~~

===Crystal structure of Mcl-1 in complex with the BaxBH3 domain===

~~{{ABSTRACT_PUBMED_021199865}}~~

==Function==

[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> [[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>

==About this Structure==

[[3pk1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PK1 OCA].

[[3pk1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PK1 OCA].

==See Also==

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==Reference==

[[Category: ~~Homo sapiens~~]]

[[Category: Human]]

[[Category: Colman, P M.]]

[[Category: Czabotar, P E.]]

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@@ Line 1: / Line 1: @@
-[[Image:3pk1.png|left|200px]]
 {{STRUCTURE_3pk1|  PDB=3pk1  |  SCENE=  }}
 ===Crystal structure of Mcl-1 in complex with the BaxBH3 domain===
+{{ABSTRACT_PUBMED_21199865}}
-{{ABSTRACT_PUBMED_021199865}}
+==Function==
+[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>  [[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
 ==About this Structure==
-[[3pk1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PK1 OCA].
+[[3pk1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PK1 OCA].
 ==See Also==
@@ Line 14: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:021199865</ref><references group="xtra"/>
+<ref group="xtra">PMID:021199865</ref><references group="xtra"/><references/>
-[[Category: Homo sapiens]]
+[[Category: Human]]
 [[Category: Colman, P M.]]
 [[Category: Czabotar, P E.]]