4mda: Difference between revisions
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{{STRUCTURE_4mda| PDB=4mda | SCENE= }} | |||
===Structure of Mos1 transposase catalytic domain and Raltegravir with Mn=== | |||
{{ABSTRACT_PUBMED_24397848}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MOS1T_DROMA MOS1T_DROMA]] Mediates transposition of transposon Mos1 by a 'cut and paste' mechanism. Transposases are sequence-specific nucleases and strand transferases that catalyze transposition through an ordered series of events: sequence-specific binding of transposase to the terminal inverted repeats (IR) present at each end of the transposon, pairing of the transposon IRs in a paired-end complex (PEC), cleavage of one or both DNA strands at each transposon end, capture of target DNA, and strand transfer to insert the transposon at a new site. | |||
==About this Structure== | |||
[[4mda]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MDA OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024397848</ref><references group="xtra"/><references/> | |||
[[Category: Richardson, J M.]] | |||
[[Category: Ddd motif]] | |||
[[Category: Dna integration]] | |||
[[Category: Dna transposition]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Recombinase]] | |||
[[Category: Rnase-h fold]] | |||
[[Category: Transposon dna]] | |||
Revision as of 06:56, 22 January 2014
Structure of Mos1 transposase catalytic domain and Raltegravir with Mn
Template:ABSTRACT PUBMED 24397848
Function
[MOS1T_DROMA] Mediates transposition of transposon Mos1 by a 'cut and paste' mechanism. Transposases are sequence-specific nucleases and strand transferases that catalyze transposition through an ordered series of events: sequence-specific binding of transposase to the terminal inverted repeats (IR) present at each end of the transposon, pairing of the transposon IRs in a paired-end complex (PEC), cleavage of one or both DNA strands at each transposon end, capture of target DNA, and strand transfer to insert the transposon at a new site.
About this Structure
4mda is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Wolkowicz UM, Morris ER, Robson M, Trubitsyna M, Richardson JM. Structural Basis of Mos1 Transposase Inhibition by the Anti-retroviral Drug Raltegravir. ACS Chem Biol. 2014 Jan 10. PMID:24397848 doi:https://dx.doi.org/10.1021/cb400791u
