4kfz: Difference between revisions
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{{STRUCTURE_4kfz| PDB=4kfz | SCENE= }} | |||
===Crystal structure of LMO2 and anti-LMO2 VH complex=== | |||
{{ABSTRACT_PUBMED_24407558}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. | |||
==About this Structure== | |||
[[4kfz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFZ OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024407558</ref><references group="xtra"/><references/> | |||
[[Category: Chambers, J.]] | |||
[[Category: Cruz-Migoni, A.]] | |||
[[Category: Fuentes-Fernandez, N.]] | |||
[[Category: Mancini, E J.]] | |||
[[Category: Omari, K El.]] | |||
[[Category: Rabbitts, T H.]] | |||
[[Category: Sewell, H.]] | |||
[[Category: Tanaka, T.]] | |||
[[Category: Developmental protein]] | |||
[[Category: Lim domain]] | |||
[[Category: Nucleus]] | |||
[[Category: Oncoprotein]] | |||
[[Category: Proto-oncogene]] | |||
[[Category: T-cell leukemia]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription factor]] | |||
Revision as of 06:58, 22 January 2014
Crystal structure of LMO2 and anti-LMO2 VH complex
Template:ABSTRACT PUBMED 24407558
Disease
[RBTN2_HUMAN] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
Function
[RBTN2_HUMAN] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
About this Structure
4kfz is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Sewell H, Tanaka T, Omari KE, Mancini EJ, Cruz A, Fernandez-Fuentes N, Chambers J, Rabbitts TH. Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. Sci Rep. 2014 Jan 10;4:3643. doi: 10.1038/srep03643. PMID:24407558 doi:https://dx.doi.org/10.1038/srep03643
