4nh9: Difference between revisions
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{{STRUCTURE_4nh9| PDB=4nh9 | SCENE= }} | |||
===Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity=== | |||
{{ABSTRACT_PUBMED_24332488}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ENPL_HUMAN ENPL_HUMAN]] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.<ref>PMID:18264092</ref> | |||
==About this Structure== | |||
[[4nh9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NH9 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024332488</ref><references group="xtra"/><references/> | |||
[[Category: Ernst, J T.]] | |||
[[Category: Zuccola, H J.]] | |||
[[Category: A/b structure]] | |||
[[Category: Chaperone]] | |||
[[Category: Endoplasmic reticulum]] | |||
Revision as of 06:58, 22 January 2014
Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
Template:ABSTRACT PUBMED 24332488
Function
[ENPL_HUMAN] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.[1]
About this Structure
4nh9 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Ernst JT, Liu M, Zuccola H, Neubert T, Beaumont K, Turnbull A, Kallel A, Vought B, Stamos D. Correlation between chemotype-dependent binding conformations of HSP90alpha/beta and isoform selectivity-Implications for the structure-based design of HSP90alpha/beta selective inhibitors for treating neurodegenerative diseases. Bioorg Med Chem Lett. 2014 Jan 1;24(1):204-8. doi: 10.1016/j.bmcl.2013.11.036., Epub 2013 Nov 23. PMID:24332488 doi:https://dx.doi.org/10.1016/j.bmcl.2013.11.036
- ↑ Christianson JC, Shaler TA, Tyler RE, Kopito RR. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol. 2008 Mar;10(3):272-82. doi: 10.1038/ncb1689. Epub 2008 Feb 10. PMID:18264092 doi:https://dx.doi.org/10.1038/ncb1689
