4bth: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===The LeuA146Trp,PheB24Tyr Double Mutant of the Quorum Quenching N-acyl Homoserine Lactone Acylase PvdQ Has an Altered Substrate Specificity Towards Small Acyl Chains===

~~The entry 4bth is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE]] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref>

~~Authors~~: ~~Koch, G., Nadal Jimenez, P., Reis, C.R., Muntendam, R., Bokhove, M., Melillo, E., Dijkstra, B.W., Cool, R~~.H.~~, Quax, W~~.J.

==About this Structure==

[[4bth]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTH OCA].

~~Description~~: ~~The LeuA146Trp~~,~~PheB24Tyr Double Mutant of the~~ Quorum ~~Quenching N-acyl Homoserine Lactone Acylase PvdQ Has an Altered Substrate Specificity Towards Small Acyl Chains~~

==Reference==

[[Category: Acyl-homoserine-lactone acylase]]

[[Category: Bokhove, M.]]

[[Category: Cool, R H.]]

[[Category: Dijkstra, B W.]]

[[Category: Koch, G.]]

[[Category: Melillo, E.]]

[[Category: Muntendam, R.]]

[[Category: Nadal-Jimenez, P.]]

[[Category: Quax, W J.]]

[[Category: Reis, C R.]]

[[Category: Hydrolase]]

[[Category: Quorum quenching]]

[[Category: Zymogen]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bth|  PDB=4bth  |  SCENE=  }}
+===The LeuA146Trp,PheB24Tyr Double Mutant of the Quorum Quenching N-acyl Homoserine Lactone Acylase PvdQ Has an Altered Substrate Specificity Towards Small Acyl Chains===
-The entry 4bth is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE]] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref>
-Authors: Koch, G., Nadal Jimenez, P., Reis, C.R., Muntendam, R., Bokhove, M., Melillo, E., Dijkstra, B.W., Cool, R.H., Quax, W.J.
+==About this Structure==
+[[4bth]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTH OCA].
-Description: The LeuA146Trp,PheB24Tyr Double Mutant of the Quorum Quenching N-acyl Homoserine Lactone Acylase PvdQ Has an Altered Substrate Specificity Towards Small Acyl Chains
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Acyl-homoserine-lactone acylase]]
+[[Category: Bokhove, M.]]
+[[Category: Cool, R H.]]
+[[Category: Dijkstra, B W.]]
+[[Category: Koch, G.]]
+[[Category: Melillo, E.]]
+[[Category: Muntendam, R.]]
+[[Category: Nadal-Jimenez, P.]]
+[[Category: Quax, W J.]]
+[[Category: Reis, C R.]]
+[[Category: Hydrolase]]
+[[Category: Quorum quenching]]
+[[Category: Zymogen]]