4m10: Difference between revisions
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{{STRUCTURE_4m10| PDB=4m10 | SCENE= }} | |||
===Crystal Structure of Murine Cyclooxygenase-2 Complex with Isoxicam=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref> | |||
==About this Structure== | |||
[[4m10]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M10 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Prostaglandin-endoperoxide synthase]] | |||
[[Category: Banerjee, S.]] | |||
[[Category: Ghebreelasie, K.]] | |||
[[Category: Hermanson, D J.]] | |||
[[Category: Marnett, L J.]] | |||
[[Category: Xu, S.]] | |||
[[Category: Cox]] | |||
[[Category: Dioxygenase]] | |||
[[Category: Glycosylation]] | |||
[[Category: Nsaid]] | |||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | |||
[[Category: Peroxidase]] | |||
Revision as of 07:04, 22 January 2014
Crystal Structure of Murine Cyclooxygenase-2 Complex with Isoxicam
Function
[PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.[1] [2] [3] [4]
About this Structure
4m10 is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ. A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J Biol Chem. 2003 Nov 14;278(46):45763-9. Epub 2003 Aug 18. PMID:12925531 doi:https://dx.doi.org/10.1074/jbc.M305481200
- ↑ Vecchio AJ, Simmons DM, Malkowski MG. Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16;285(29):22152-63. Epub 2010 May 12. PMID:20463020 doi:10.1074/jbc.M110.119867
- ↑ Duggan KC, Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA, Marnett LJ. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J Biol Chem. 2010 Nov 5;285(45):34950-9. Epub 2010 Sep 1. PMID:20810665 doi:10.1074/jbc.M110.162982
- ↑ Vecchio AJ, Malkowski MG. The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. J Biol Chem. 2011 Jun 10;286(23):20736-45. Epub 2011 Apr 13. PMID:21489986 doi:10.1074/jbc.M111.230367
