361d: Difference between revisions

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==Overview==

The synthetic RNA fragment 5'-CUGGGCGG(GCGA)CCGCCUGG (nucleotides in, parentheses indicate the loop region) corresponds to the natural sequence, of domain E from nucleotides 79-97 of the Thermus flavus 5S rRNA including, a hairpin loop. The RNA structure determined at 3.0 A and refined to an, R-value of 24.1% also represents the first X-ray structure GNRA tetraloop., The loop is in distinctly different conformation from other GNRA, tetraloops analyzed by NMR. The conformation of the two molecules in the, asymmetric unit is influenced and stabilized by specific intermolecular, contacts. The structural features presented here give evidence for the, ability of RNA molecules to adapt to specific environments.

The synthetic RNA fragment 5'-CUGGGCGG(GCGA)CCGCCUGG (nucleotides in parentheses indicate the loop region) corresponds to the natural sequence of domain E from nucleotides 79-97 of the Thermus flavus 5S rRNA including a hairpin loop. The RNA structure determined at 3.0 A and refined to an R-value of 24.1% also represents the first X-ray structure GNRA tetraloop. The loop is in distinctly different conformation from other GNRA tetraloops analyzed by NMR. The conformation of the two molecules in the asymmetric unit is influenced and stabilized by specific intermolecular contacts. The structural features presented here give evidence for the ability of RNA molecules to adapt to specific environments.

==About this Structure==

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[[Category: Protein complex]]

[[Category: Betzel, C.]]

[[Category: Erdmann, V.A.]]

[[Category: Erdmann, V A.]]

[[Category: Lorenz, S.]]

[[Category: Nolte, A.]]

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[[Category: tetraloop]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:02:18 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The synthetic RNA fragment 5'-CUGGGCGG(GCGA)CCGCCUGG (nucleotides in, parentheses indicate the loop region) corresponds to the natural sequence, of domain E from nucleotides 79-97 of the Thermus flavus 5S rRNA including, a hairpin loop. The RNA structure determined at 3.0 A and refined to an, R-value of 24.1% also represents the first X-ray structure GNRA tetraloop., The loop is in distinctly different conformation from other GNRA, tetraloops analyzed by NMR. The conformation of the two molecules in the, asymmetric unit is influenced and stabilized by specific intermolecular, contacts. The structural features presented here give evidence for the, ability of RNA molecules to adapt to specific environments.
+The synthetic RNA fragment 5'-CUGGGCGG(GCGA)CCGCCUGG (nucleotides in parentheses indicate the loop region) corresponds to the natural sequence of domain E from nucleotides 79-97 of the Thermus flavus 5S rRNA including a hairpin loop. The RNA structure determined at 3.0 A and refined to an R-value of 24.1% also represents the first X-ray structure GNRA tetraloop. The loop is in distinctly different conformation from other GNRA tetraloops analyzed by NMR. The conformation of the two molecules in the asymmetric unit is influenced and stabilized by specific intermolecular contacts. The structural features presented here give evidence for the ability of RNA molecules to adapt to specific environments.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Protein complex]]
 [[Category: Betzel, C.]]
-[[Category: Erdmann, V.A.]]
+[[Category: Erdmann, V A.]]
 [[Category: Lorenz, S.]]
 [[Category: Nolte, A.]]
@@ Line 23: / Line 23: @@
 [[Category: tetraloop]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:36:40 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:02:18 2008''