2c2n: Difference between revisions
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{{STRUCTURE_2c2n| PDB=2c2n | SCENE= }} | {{STRUCTURE_2c2n| PDB=2c2n | SCENE= }} | ||
===Structure of human mitochondrial malonyltransferase=== | |||
{{ABSTRACT_PUBMED_19549604}} | |||
== | ==Function== | ||
[[http://www.uniprot.org/uniprot/FABD_HUMAN FABD_HUMAN]] Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias.<ref>PMID:12882974</ref> | |||
==About this Structure== | |||
[[2c2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2N OCA]. | |||
== | ==Reference== | ||
<ref group="xtra">PMID:019549604</ref><references group="xtra"/><references/> | |||
[[Category: | [[Category: Human]] | ||
[[Category: Arrowsmith, C.]] | [[Category: Arrowsmith, C.]] | ||
[[Category: Bunkoczi, G.]] | [[Category: Bunkoczi, G.]] | ||
[[Category: Delft, F | [[Category: Delft, F von.]] | ||
[[Category: Edwards, A.]] | [[Category: Edwards, A.]] | ||
[[Category: Oppermann, U.]] | [[Category: Oppermann, U.]] | ||
Revision as of 05:39, 29 January 2014
Structure of human mitochondrial malonyltransferase
Template:ABSTRACT PUBMED 19549604
Function
[FABD_HUMAN] Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias.[1]
About this Structure
2c2n is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Bunkoczi G, Misquitta S, Wu X, Lee WH, Rojkova A, Kochan G, Kavanagh KL, Oppermann U, Smith S. Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases. Chem Biol. 2009 Jun 26;16(6):667-75. doi: 10.1016/j.chembiol.2009.04.011. PMID:19549604 doi:https://dx.doi.org/10.1016/j.chembiol.2009.04.011
- ↑ Zhang L, Joshi AK, Smith S. Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. J Biol Chem. 2003 Oct 10;278(41):40067-74. Epub 2003 Jul 25. PMID:12882974 doi:https://dx.doi.org/10.1074/jbc.M306121200
