4fc2: Difference between revisions

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[[Image:4fc2.jpg|left|200px]]
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{{STRUCTURE_4fc2|  PDB=4fc2  |  SCENE=  }}  
{{STRUCTURE_4fc2|  PDB=4fc2  |  SCENE=  }}  
===Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain===
===Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain===


==Function==
[[http://www.uniprot.org/uniprot/PARG_MOUSE PARG_MOUSE]] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).


==About this Structure==
==About this Structure==
[[4fc2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FC2 OCA].  
[[4fc2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FC2 OCA].  
[[Category: Mus musculus]]
[[Category: Lk3 transgenic mice]]
[[Category: Cheng, Z.]]
[[Category: Cheng, Z.]]
[[Category: Wang, Z.]]
[[Category: Wang, Z.]]

Revision as of 06:12, 29 January 2014

Template:STRUCTURE 4fc2

Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain

Function

[PARG_MOUSE] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).

About this Structure

4fc2 is a 4 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

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