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| {{STRUCTURE_4lxe| PDB=4lxe | SCENE= }}
| | #REDIRECT [[4man]] This PDB entry is obsolete and replaced by 4man |
| ===Bcl_2-Navitoclax Analog (with Indole) Complex===
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| {{ABSTRACT_PUBMED_23291630}}
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| ==Disease==
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| [[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. | |
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| ==Function==
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| [[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>
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| ==About this Structure==
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| [[4lxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ochroconis_lascauxensis Ochroconis lascauxensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXE OCA].
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| ==Reference==
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| <ref group="xtra">PMID:023291630</ref><references group="xtra"/><references/>
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| [[Category: Ochroconis lascauxensis]]
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| [[Category: Park, C H.]]
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| [[Category: 8 helice]]
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| [[Category: Apoptosis regulator-inhibitor complex]]
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Latest revision as of 07:33, 29 January 2014
This PDB entry is obsolete and replaced by 4man
