4lrx: Difference between revisions
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{{STRUCTURE_4lrx| PDB=4lrx | SCENE= }} | |||
===Crystal Structure of the E.coli DhaR(N)-DhaK complex=== | |||
{{ABSTRACT_PUBMED_24440518}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DHAK_ECOLI DHAK_ECOLI]] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone. [[http://www.uniprot.org/uniprot/DHAR_ECOLI DHAR_ECOLI]] Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own synthesis. | |||
==About this Structure== | |||
[[4lrx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRX OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024440518</ref><references group="xtra"/><references/> | |||
[[Category: Cygler, M.]] | |||
[[Category: Ekiel, I.]] | |||
[[Category: McDonald, L.]] | |||
[[Category: Shi, R.]] | |||
[[Category: Coiled-coil]] | |||
[[Category: Gaf]] | |||
[[Category: Helix rotation]] | |||
[[Category: Pa]] | |||
[[Category: Transcription regulation complex]] | |||
[[Category: Transferase-transcription regulator complex]] | |||
Revision as of 07:38, 29 January 2014
Crystal Structure of the E.coli DhaR(N)-DhaK complex
Template:ABSTRACT PUBMED 24440518
Function
[DHAK_ECOLI] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone. [DHAR_ECOLI] Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own synthesis.
About this Structure
4lrx is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Shi R, McDonald L, Cygler M, Ekiel I. Coiled-Coil Helix Rotation Selects Repressing or Activating State of Transcriptional Regulator DhaR. Structure. 2014 Jan 14. pii: S0969-2126(13)00471-1. doi:, 10.1016/j.str.2013.11.012. PMID:24440518 doi:https://dx.doi.org/10.1016/j.str.2013.11.012
